Based on the Molecular Mechanism of CiteSpace Sanqi Total Saponin and the Prevention and Treatment of Renal Fibrosis, Hot Spot Visualization Analysis

Abstract

This study aims to study the current situation, hot spots and development trends of Sanqi total saponins in the prevention and treatment of renal fibrosis through a visual map, in order to provide a direction and trend for the research of traditional Chinese medicine on the prevention and treatment of renal fibrosis. Method: By using CiteSpace visualization software, the relevant literature on the use of Sanqi total saponins in the CNKI database for the treatment of renal fibrosis was visually analyzed, including posting trends, authors, institutions and keywords, and the corresponding knowledge map was generated. Results: From 2005 to 2022, a total of 1,533 documents were included in the research results. From 2008 to 2017, an average of 99 articles were published every year, accounting for 67.5% of the total number of articles published. Among them, the number of articles published in 2010 and 2013 reached 114, the highest in previous years. At the same time, Yang Min is the author who has published the most articles, with a total of 29 papers. Beijing University of Traditional Chinese Medicine is the main research institution in this field. Through cluster analysis of research hotspots, ten clusters were obtained, including rats, left ventricular reconstruction, oxidative stress, drug interaction, astragaloside, apoptosis, matrix metalloproteinase-9,oleoside, lipopolysaccharide, atherosclerosis, etc. Future research focuses include oxidative stress, autophagy process, Sanqi total saponins, inflammatory response, cell proliferation and apoptosis, and pharmacokinetics. Conclusion: The knowledge map reveals the research status and research hotspots of Sanqi total saponins in the prevention and treatment of renal fibrosis, including oxidative stress, inflammation, cell proliferation and apoptosis, which will become the focus of research on the prevention and treatment of renal fibrosis in traditional Chinese medicine in the future. However, the collaboration between research authors and scientific research institutions lacks closeness, lacks core authors, and has not yet formed an influential research organization. The depth and breadth of research need to be further enhanced.