An Overview of the Cure of HIV/AIDS Harbal Therapy Containing Natural Antioxidant, Vitamins and Minerals

Purposes: The unprecedented and sequence through which an estimate of 25 million lives have gone to their early grave yard through Acquired Immune-deficiency Syndrome HIV/AIDS can never be quantified; since, when it was first describes in 1981. In 2017/2018 by (UNAIDS) it was estimated globally for about 36.9millions people were living with Human, Immunodeficiency Virus (HIV) so to say. Henceforth the progress made in the field of treatment in the form of Antiretroviral Therapy (ART) disease has not been fully ascertain for the cure of HIV/AIDS; except, perpetual clinical suppressions. Thus, the current challenges that man kinds faces with the used of perpetual intake of antiretroviral therapy (clinical suppression)/artificial vaccine is un-justifiable. However, search for HIV therapy have open a new chapter in the search for novel drugs from Kaduna Polytechnic procedure. This review focuses on vitamins, antioxidant, mineral and supplement as sources of in-hibitors or eradications for human immunodeficiency virus type-1 (HIV) reverse transcriptase. Objective: To assess whether vitamins, antioxidant, minerals supplement are effective and safe in eradicating mortality and morbidity among populace with HIV infection. Selection criteria: Randomized control trials were selected that compared the effect of vitamins (A, C, D, E, K,), antioxidant, minerals and supplement with regard to treatment measures in HIV infected persons. Methods: To prevent authors bias, based on a systematic search of literature; anti-HIV reverse transcriptase activity of some plant’s species like those of Eucalyptus leaves, Garlic fresh fruits, Baobab leaves, aloe vera, neem leaves, moringa leaves, bitter leaves etc. respectively. Thus, these medicinal plants contain an appreciable or above values antioxidant compound or photochemical like those of Phenolic, anthraquinone, tannin, falconoid, terpenoid, lignin, coumarins etc. respectively. Contrarywise, these phytochemical compounds have been exploited traditionally for the cure of many diseases as well as inhibition of viral replication/transcription. Further investigations have shared more light through which phytochemicals compounds inhibit virus replication either during the http://www.scholink.org/ojs/index.php/se Sustainability in Environment Vol. 6, No. 3, 2021 27 Published by SCHOLINK INC. viral entry inside the host cell or during their replication. Originality: in view of the current investigation or to accelerate drug discovery and innovation, this review recommends the urgent need to tap into the enrich locally available endogenous knowledge of putative antiHIV/AIDS, photochemical and their derivatives, (reverse pharmacology, determine pan assay, interferences compounds, microbial enzyme metabolites relationship and their mechanisms to treat virial diseases.


Introduction
The HIV epidemic is receding globally with a 38% drop in new infections (UNAIDS, 2014); however, it continues to pose as a major global public health challenge. The goal of an effective vaccine still remains elusive. Anti-Retroviral Treatment (ART) has increased the life span of People Living With HIV (PLHIV) and 14.9 million people globally are receiving ART (WHO, 2015). Even though the mainstream highly active anti-retroviral therapy (HAART) potently suppresses the plasma HIV-1 viral load, it is unable to eradicate HIV completely. Therefore, there is a lifelong requirement for ART which will decrease the morbidity due to drug toxicity and acquisition of resistance. Considering this, there is a continuous need to explore safe and efficacious anti-retroviral agents; which is a challenge that needs to be addressed through integrated approaches. Azidothymidine (AZT)-a NRTI drug was the first accidental breakthrough in HIV therapy in 1980's with its origin from cancer research on photochemical. Acyclovir, Val acyclovir and various HIV protease inhibitors are subsequent statutory examples following this trend. This can be attributed to the fact that the chemical novelty for chemical scaffolds in natural products is 40% higher than any other source. Although natural products are extensively studied for anti-HIV activity, majority of these studies are restricted to preliminary screenings that aren't pursued to the molecular level with allied approaches for substantiated outcomes. to child: Women can transmit HIV to their offspring throughout gestation or birth. HIV can also be transmitted through in discriminate sexual intercourse women and about 90% of the infections is obviously from sexual intercourse

Primary HIV Infection
The effects of primary HIV infection on micronutrient status have not been studied. Nonetheless, it is conceivable that the acute HIV syndrome, with fever, anorexia, nausea, and diarrhea followed by weight loss, may impair micronutrient status. However, because the acute stage is transient, it is mainly of concern in individuals with prior poor micronutrient status or lack of access to an adequate convalescent diet. Such deficiencies, precipitated or exacerbated by a symptomatic primary HIV infection, could be pivotal by affecting the viral load set point and host defense and thereby affecting HIV transmission and progression.

Asymptomatic HIV Infection
Little acute phase response occurs during the long asymptomatic stage of HIV infection, but viral replication occurs continuously, leading to the slow but relentless increase in viral load over a number of years. Changes in the structure and function of the intestinal tract seem to occur relatively early in HIV infection. An HIV entero pathy characterized by villous atrophy and crypt hyperplasia and accompanied by malabsorption has been described in HIV-positive individuals. Reduced absorption likely leads to impaired micronutrient status at this stage, which may be important because of the stage's long duration.
Few studies on micronutrient status have been conducted with asymptomatic HIV-positive individuals and appropriate comparison groups. However, some studies have been done in developing countries in pregnant women attending antenatal care. HIV-positive pregnant women are usually at an early stage of infection, partly because even early HIV infection reduces fertility and increases fetal loss. Accordingly, http://www.scholink.org/ojs/index.php/se Sustainability in Environment Vol. 6, No. 3, 2021 31 Published by SCHOLINK INC.
among 1669 Zimbabwean pregnant women, those with HIV infection had mean viral load of 3.85 log and morbidity, body composition and serum α 1 -antichymotrypsin similar to values for HIV-negative women. Nonetheless, serum retinol and β-carotene were considerably lower and α-tocopherol, ferrit in and folate were slightly but significantly lower after adjustment was made for elevated acute phase proteins. These differences most likely reflect increased requirements in HIV-positive individuals but this could not be substantiated because intake was not controlled for.
In this developing country setting, most women seek antenatal care when pregnant and are rarely aware of their HIV status. Although selection bias is therefore not likely to be a problem, HIV-positive and -negative women may not have comparable socioeconomic backgrounds. Confounding cannot be excluded because poor socioeconomic status may be associated with unprotected sex and HIV infection and be a cause of poor micronutrient status. Controlling for dietary intake and possibly other socioeconomic factors is therefore critical.

Symptomatic HIV Infection
During symptomatic HIV infection, the effects of HIV in the gastrointestinal tract are more severe. The increasingly frequent enteric and other infections result in both acute phase responses and localized lesions which further exacerbate an impaired micronutrient status.
A number of early studies from developed countries, before the use of ARV drugs, reported low serum levels of several micronutrient indicators, such as vitamin A; arytenoids; vitamins B 6 , B 12 , C and E; folate; as well as selenium and zinc in adults and children. However, these studies were mostly hospital based and contained little information about the stage of HIV infection and how HIV-positive and -negative controls were selected. Furthermore, the acute phase response was not controlled for, which leads to overestimation of the association between HIV and deficiencies for some of the micronutrients.
Many patients may have taken supplements in response to their HIV diagnosis and confections. This may have led to gross underestimation of the effect of HIV infection on micronutrient status, making it difficult to base conclusions on these data.
One study attempted to control for the intake of micronutrients and will therefore be mentioned in more detail. This cross-sectional study was conducted in 108 HIV-positive homosexual men in United States.
Serum vitamins A, B 6 , B 12 and E and serum zinc were assessed and compared with values for 38 HIV-negative homosexual men. All subjects were selected from hospitals, clinics or community programs. All were free from other diseases, but 19% of the HIV-positive men had symptoms and 90% had normal weight. HIV-positive men had higher triceps skin fold thickness than did the HIV-negative men. More HIV-positive men took supplements and had a higher total intake of all micronutrients than did HIV-negative men. In fact, most HIV-positive men had intakes above the recommended dietary allowance. Intakes at or above the recommended dietary allowance were associated with normal plasma levels in the HIV-negative men. In contrast, in HIV -positive men even intakes several times the recommended dietary allowances were not associated with adequate serum levels. No attempt was made to control for the acute phase response, and data were not given separately for subjects with and http://www.scholink.org/ojs/index.php/se Sustainability in Environment Vol. 6, No. 3, 2021 32 Published by SCHOLINK INC.
without symptoms. The authors concluded that intake of nutrients at levels recommended for the general population did not appear adequate for HIV-1-positive men. Despite its limitations, this study has contributed considerably to the widespread notion that HIV-positive individuals need multiples of recommended dietary allowances.
Prevention and prompt treatment of opportunistic infections and effective ART will most likely reduce the effect of HIV infection on micronutrient status. For example, antioxidant status is considerably improved in patients on protease inhibitors. Nevertheless, drugs often have adverse effects, such as nausea, vomiting and diarrhea, or affect micronutrient metabolism, resulting in a negative effect on micronutrient status.

Sexual Transmission
Sexual transmission depends on infectivity of the HIV-positive individual as well as susceptibility of In Kigali, Rwanda, a cohort of sexually active women was followed every 6 months for 24 months. No differences were noted for serum concentrations of retinol, arytenoids, vitamin E, ferritin and selenium between 45 women who seroconverted and 74 randomly selected women who did not. HIV-negative adults attending sexually transmitted disease clinics in Pune, India, were enrolled in a cohort and followed every 3 months for HIV infection. Serum retinol, various carotenoids and vitamin E concentrations were determined for 44 participants who later seroconvert and for 44 matched HIV-negative controls. The time between the visit when vitamin status was determined and the visit when the participant first was found to have HIV seroconvert was 6 months. Serum βcarotene below 0.075 µmol/L (i.e., the upper tertial) was associated with an increased risk of seroconversion (odds ratio After treatment, the some men were tested for HIV infection at 3month intervals; mean follow-up time was 6 months. For each participant who seroconvert, two or three consecutive participants who remained HIV negative were included as controls. Surprisingly, although there were no differences in socioeconomic status and history of unprotected sex, the 38 sero-converters had higher baseline serum retinol values than did the 94 controls. Serum retinol greater than 0.70 µmol/L was associated with a greater than two-fold increased risk of seroconversion. The authors suggest that the results may be due to an effect of vitamin A on differentiation of target cells of the monocyte/macrophage lineage in the mucosa, as previously reported.

Herbal Medicine
Herbal medicine   Suksdorfin is another compound that also has inhibitory effects on replication of the virus in the T cell line and is a pyrocoumarin derivative that can be extracted from the Angelica morii and Lomatiumsuksdorfii fruits from the Apiaceae family as seen in table 1 and 4.

Terpenes
Antiretroviral activity with diverse mechanisms of action have been observed with some triterpenoids.  Xanthohumol, a prenylchalcone that has demonstrated inhibition of HIV-1 and is extracted from hops Humuluslupulus.

Alkaloids
Different types of alkaloids have shown anti-HIV activity. One of the natural products with interesting activity on RT is polycitone A (asseen in Table 1

Phenolics
Because of heightened phytohaemagglutinin-induced lymphocytes proliferation, prolonged administration of polyphenol-rich fruit juices is believed to be promising to HIV-positive individuals.
There are several tannins and related phenolic substances which show virucidal effects in several viral systems. Lithospermic acid isolated from Salvia miltiorrhiza has strong anti-HIV activity in H9 cells.

Saponins
Actein is a tetracyclic triterpenoid saponin that exhibits strong anti-HIV activity and derives from the rhizome of Cimicifuga racemosa (black cohosh).

Xanthones
Swertifrancheside is a flavonone-xanthone glucoside that has shown inhibition of HIV-1 RTase and is extracted from Swertia franchetiana .Macluraxanthone B is a prenylated xanthone that also shows anti-HIV activity and is extracted from Maclura tinctoria of the Moraceae family.

Also termed
Primary metabolites are also termed as central metabolites.
Secondary metabolites are also termed as specialized metabolites.

Growth phase
Primary metabolites are produced during the growth phase of the organism.
Secondary metabolites are produced during the stationary phase of the organism.
This phase of growth is also termed as "trophophase".
This phase of growth is also termed as "idiophase".

Quantity
Primary metabolites are produced in large quantities.
Secondary metabolites are produced in small quantities.

Extraction
It is easier to extract primary metabolites.
It is difficult to extract secondary metabolites.

Specificity
Primary metabolites are not species-specific and thus might be identical in some organisms. Oxygen is essential to sustaining normal cell function, and ultimately, aerobic life. All living aerobic organisms require dioxygen as an electron acceptor for efficient energy production and a signaling molecule in biological processes. However, it is constantly facing a paradox in which the breakdown of its products may be detrimental to cell function and survival. Therefore, reducing oxidants to physiological levels presents a complicated task.

Antioxidants
Antioxidants are either naturally occurring or synthetic bimolecular that prevent free radical induced damage by averting the formation of radicals, scavenging them, or promoting their decomposition in the body. Their neutralizing capabilities reside in their ability to donate an electron to ward off the deleterious effects of the highly reactive radicals or by converting ROS into different, less harmful, molecules. Antioxidants come in a variety of forms, ranging from those generated endogenously by the body to others administered exogenously as dietary supplements. When the natural balance between oxidants and antioxidants within the body is disturbed via antioxidant deficiency or increased ROS production, oxidative stress results. The subsequent adverse effects have appeared to be diminished, and sometimes resolved, through bodily antioxidant defense and supplementation.
A Free radicals once again is a molecules that contain an unpair electron in it outer orbit and that can exist independently or rather free radical are unstable atomic/molecule species because of their one or more unpaired electron. There minimizing the influence of free radicals requires an antioxidant.
Antioxidant can be divided in to two forms they are as follows: Synthetic

Synthetic Antioxidant
The use of synthetic antioxidants is quite hazardous for health because of its side effect, and it is however more or less use in the production of Antiretroviral viral therapy (ART) for HIV carrier patients and Covid-19 artificial vaccine. Thus, it has been reported to be quite hazardous and side effect.
The side effect caused by using synthetic antioxidant when it lingers in the body is liver swollen, diabetes, high blood pressure, piles etc. respectively.
Plate 2. Posts the Researcher and the Village Head of Ishibori Trying to win His Heart on the Divine Herbal Therapy

d. Natural antioxidant
The use of natural antioxidant is by far much safer and beneficial for health and has much lower toxicity as seen in table 1, Some studies have been reported that supplement with vitamins C , E and antioxidant or antioxidant mixture can reduce symptom or indicators of oxidative stress as a results of exercise. Exercise training seems to reduce the oxidative stress of exercise such that train athletes showed less evidence of lipid peroxidation

c. Oxidative Stress
Excessive levels of ROS may be generated through over stimulation of the otherwise tightly regulated NADPH oxidase or by other mechanisms that generate ROS in a nonregulated fashion. An overload of free radicals and oxidants leads to their accumulation in the body, a phenomenon known as Oxidative Stress (OS). Generally, free radical production is counterbalanced by several mechanisms that include both enzymatic and non-enzymatic antioxidants. However, in times of imbalance between ROS and the body's antioxidant scavengers, OS ensues. OS may be a consequence of excess ROS production and/or reduced antioxidant capacity. The inability of the human biological system to detoxify and reduce oxidants or to repair detrimental damage disrupts physiological homeostasis. OS has been implicated in the pathogenesis of many other human diseases including cancer, diabetes, Parkinson disease, and even   great rate. However, the degree at which the virus is generated is much greater to that of the CD4 cells.

AIDS.
It is believed that HIV does not kill by gradually undermining the immune system's ability to produce helper CD4 cells, but rather by overwhelming the finite regenerative capacity of the system. Furthermore, AIDS is triggered when the infecting virus mutates and diversifies into so many different strains that the immune system is suddenly overpowered. The diverse variations of HIV strains are different enough from the original to elude the immune system.
Ever since its first isolation in 1984, HIV has generally been accepted as the causative agent of AIDS.
However, the discovery of HIV also led to a broadening of the view that ROS play a critical role in the expression of HIV and the development of AIDS .It has been reported that the virus induces OS by disturbing cellular antioxidant defense and initiating oxidative reactions. Advanced cases of HIV infection render individuals susceptible to opportunistic infections, which take advantage of the progressive immunodeficiency caused by HIV. Since cellular redox status is a normal physiological variable, any imbalance may elicit cellular response through proliferation, transcriptional activation, or apoptosis. For this reason, recent reports suggest that OS is a principal mechanism in the progression of AIDS.   Tat is known to increase HIV transcription rates. It is thought to bind to cellular factors and mediate their phosphorylation. This results in an increase in transcription of all HIV genes Tat has been shown to induce OS. One study revealed that tat protein expression from HIV-1 infected HeLa cells amplified the activity of tumor Necrosis Factor (TNF), which stimulated HIV-1 replication through the activation of nuclear factor-kappa B (NF-κB) .Furthermore, this report found NF-κB activation to be involved in the formation of reactive oxygen intermediates, while suppressing the expression of Mn-dependent superoxide dismutase (Mn-SOD) involved in the cellular defense system against OS. Specifically, the C-terminal region of HIV-1 tat suppressed Mn-SOD expression. This induced pro-oxidative condition was reflected in a lowered ratio between reduced and oxidized glutathione. These findings suggest that tat-mediated events affect cellular redox state, and that antioxidant therapy may potentially deplete oxidant levels, reducing NF-κB activation, transcription of HIV, and disease progression. It is suggested that a reduction in the elevated oxidant levels found in the cytoplasm upon infection may be attained through antioxidant treatment. Subsequently, NF-κB would remain bound to IκB and unable to pass through the nuclear membrane to transcribe. Glutathione, a major intracellular thiol, has been associated with inhibition of NF-κB by scavenging free radicals within the cytosol. Since Fas activation is associated with NF-κB, inactivation or impairment of the Fas membrane receptor's binding site may not only lower levels of CD4 + T-cell depletion, but also reduce HIV transcription rates.
This could potentially decrease disease progression.  The low hemoglobin observed in HIV infection may, paradoxically, be associated with high plasma ferritin levels, as well as iron accumulation in bone marrow, liver, macrophages, and brain and muscles cells. Elevated serum ferritin levels have been associated with more frequent infections and shorter survival times in patients with HIV infection in an observational study . In reticulocytopenia, common in HIV-associated anemia, endogenous erythropoietin is low, and a blunted erythropoietin feedback mechanism may contribute substantially to the relatively high prevalence of anemia in HIV-infected patients . However, iron deficiency is a common cause of anemia in HIV infection, particularly in women in inner cities whose nutrient intakes have been found to be inadequate, and in children from sub-Saharan and East Africa where the prevalence of HIV infection coincides with high prevalence of malnutrition and iron deficiency. In iron deficiency anemia, supplementation is needed to reverse the deficiency, and adequate dietary intake of iron through the course of the disease and treatment is critical to prevent the condition. The treatment of severe anemia in HIV-1-infected patients is critical, as recovery from anemia has been associated with increased length of survival in these patients . Oral or parenteral therapy for anemia in iron deficient HIV-infected children has resulted in an improved production of hemoglobin. Calis et al. Iron deficiency has been hypothesized to act synergistically with antiretroviral agents in inhibiting HIV-1 replication. In support of this hypothesis, an in vitro study demonstrated that iron-chelating agents, such as deferoxamine, inhibit proliferation of HIV-infected mononuclear blood cells. Iron-chelating agents render iron catalytically inactive, and enhance the action of some antiretroviral agents in vitro, using specimens from HIV-infected individuals. In addition, iron withdrawal from HIV-infected β-thalassemic subjects has been associated with protection against progression to AIDS. Additional evidence indicates that coadministration of low doses of oral iron and dapsone to prevent Pneumocystis carinii jiroveci

b. Selenium
Selenium is the active component of the enzyme glutathione peroxidase in humans and may have a role in slowing down the growth of cancerous tumors. In animal models, selenium deficiency impairs the ability of phagocytic neutrophils and macrophages to destroy antigens. One of the mechanisms through which selenium status appears to influence humoral immune response is through its role in cytokine response. IL-2 is a Th-1 cytokine, responsible for the earliest and most rapid expansion of T lymphocytes.
In in vitro models, selenium appears to regulate and enhance the production of IL-2 through the increased expansion of high-affinity cytokine receptors in a dose-dependent manner.

Plate 8. Posts the Already Finish Encapsulated Covid-19 Capsule
Selenium deficiency, prior to ART, has been shown to be predictive of HIV-related prognosis and survival, and deficient selenium maternal status, if not reversed, has been found to be associated with higher risk of intrapartum transmission, and fetal and child death. These findings have an important implication, since the prevalence of selenium deficiency ranges between 7 and 33% among various

HIV-1-infected cohorts and increases as the disease advances to AIDS.
Observational studies in HIV-1-infected chronic drug users before the advent of ART indicated that selenium deficiency was an independent predictor of survival (RR: 10.8; 95% CI: 2.37-49.2; p < 0.002) in a multivariate model that controlled for the joint effects of nutritional deficiencies that had predicted mortality in univariate analyses. This significant effect of selenium was evident when controlling for a CD4 + T-cell count of less than 200 cells/mm 3 at baseline and CD4 + T-cell count over time. When similar analyses were conducted in an observational study in a cohort of HIV-infected MSM and who were not receiving ART the odds ratio (OR) for mortality was 7.2 in those with low plasma selenium compared with those with normal selenium levels, after controlling for age, race and CD4 + T-cell count below 200 cells/mm 3 at baseline. In this cohort, selenium deficiency was also associated with decreased survival; patients with selenium deficiency lived for 31.4 months, compared with 57.4 months for those with normal plasma selenium levels after controlling for CD4 + T-cell levels, viral load and antiretroviral medications.
In an observational study of HIV-1-infected children in the pre-ART era, selenium deficiency has been associated with immune dysfunction and decreased survival. Similar pediatric findings were reported from a 2-year study of 610 children born to HIV-infected women in Tanzania who were not on ART. The results of this observational study demonstrated that the children's plasma selenium levels were inversely associated with risk of mortality for all causes. Furthermore, low maternal plasma selenium levels were significantly predictive of risks of fetal death, child death and intrapartum HIV transmission, but were associated with lower risk of delivering a child small for gestational age.

c. Zinc
Zinc is important for maintaining an intact immune system. Adequate levels of zinc are necessary for activation of lymphocytes. Zinc deficiency reduces generation of T cells, depresses humoral and cell-mediated immunity and causes lymphopenia, thymic atrophy, reduced capacity of macrophages to take up and kill parasites, and increased susceptibility to a greater number of infections. Many of these immune deficits generally correlate with the degree of zinc deficiency. Indirectly affecting and magnifying its impact on immunity, zinc deficiency also alters the membrane barrier permeability of endothelial and lung epithelial cells and causes ulcerations of the small intestine.
Zinc is essential for the function of the hormone thymulin, which is needed for the formation of T lymphocytes. In animals and humans, zinc deficiency results in a rapid and marked atrophy of the thymus,  CD4 + T-cell count, lymphocyte levels, age and calorie-adjusted dietary intake in the pre-ART era.
In an observational study in a Miami cohort of 130 HIV seropositive MSM prior to the ART era, and who were followed for 4 years, those who became zinc deficient during the study had a mean CD4 + T-cell count decline of 111 cells/mm 3 , while those who increased their plasma zinc from the deficient to the adequate range had a significant mean increase of 61 cells/mm 3 in CD4 + T-cell count (p < 0.01). The evidence shows that zinc doses above 15 mg were associated with adverse effects and are not recommended. In addition, HIV-infected populations who are zinc deficient, or at high risk of deficiency, in cohorts prior to ART or on ART, as well as patients on ART with controlled viral load, appear to benefit the most from long-term, low-level zinc supplementation. behold it reaches to a particular point in time where by people would rather have taken it in secret mannerism after which it must have worked for them so efficiently. Thus, they would always asked for more as if it have become a habit. By and large the divine fermented Naija natural HIV/AID sherbal drug/vaccine therapy does not always take the recognition or care of HIV/AIDS status but also regarded to other ailments as seen in table 3. Most of the populace received the natural herbal drugs/vaccine over 50 persons have the highest followed by over 30 persons and the least were observed within over 15 and 12 persons within the country and outside. According to them it was a welcome development and highly recommended within the concern communities both in the local, state, national as well as outside the country. But why the registration of the herbal drug by NAFDAC is so lingering and repugnant; has there been a conspiracy going on against the microbiologist who has discovered the herbal natural therapy with the so-called medical doctor in the country? A prophet is not known in his country except at another country. In addition, the fermented divine Herbal medicine once taken and the illnesses gone, ones donot need to go and lick it vomits (SIN) or like the pig that is washed and warn never to go to back to gutter by the owner. Yet the pig would secretly find itself in the gutter i.e., habitual and deliberate sin ("Zunubin Gangachi" in Hausa). The researcher has been instructed for men ought to have been living a sinless life, for without holiness no human being would evercaught a glimpse of seeing the maker of earth and heaven home. Taking a brighter way of life to reaching many that were under siege in one way or the other in Cross River States local communities namely; Igalo, Ishibori, Obugu, as well as Ogoja, the researcher motive was to go for a burial funeral of a family friends i.e., in person of late Chief George Bengioshuye Agba. For this reason, he was the son of late major Abobo Agba (Retired). In the process of time as the researcher waspreparing for the burial funeral oflate Chief George Bengioshuye Agba, a though crosses there searcher mind for God assignment to humanity (Divine fermented Naiji natural HIV/covid 19 herbal therapy. There upon the researcher obeys God's command and carry go the natural herbal medicine to Cross river state namely Igalo, Ishibori, Obugu, as well as Ogoja communities. On arrival to Ogoja area of jurisdiction, the researcher lodge in the house of Ishibori headvillage namely Chief Kennedy for two days thereafter. On the other hand, the researcher who had come to Ogoja local government area with lots of joyful good news to the communities, has fallen a bit fear within him; for how he would have related to the head village of the issue of mankind toiling with lingering killer disease like that of HIV/AIDS status.
Honestly at the very particular point in time the researcher wish it could have been diabetes, pile, Hepatitis, high blood pressure asthma ulceretc., respectively as seen in plate 2 trying to capture the man's heart so as he would have dance to the researcher's wishes. Going by the rules, it crosses the researchers mind to what must have given birth to such a multiple illness that men are habituated with.
As a matter of truth, the genealogy of those ailments came from the master Killer HIV/AIDS as instructed by the maker of heaven and earth planet. Having discussed at length with the Head village of Ishibori as mentioned with these series of illnesses namely, diabetes, pile, Hepatitis, high blood pressure asthma ulceretc respectively. Thus, the researcher deliberately failed not to have let the cat out of the bag to his knowledge, later there searcher decided to tell him where the geneses of these illnesses came from (it is not my mouth they would receive that the head of a village mess in the public).
Suddenly the head village boasted into laughter and beg the researcher to please tell him. In a twinkling of an eye there searcher read his mind for he would not have taken an offense. For this reason, the researcher opens up by saying if the medical doctors/ scientists in the world would failed to have told mankind the truth about the killer disease then the common researcher would let it known to mankind.
In Hausa language popular saying "Karya tana karewaammagaskiyabatakarewa". It simply means lies have limit but truth has no limit. H…..I……V/A…..I…D…S. The Head village mind was deeply read by the researcher of the truth the man was contemplating these things that have been in his body for long secretly and Dr. came and expose him within himself. Hmm…. History has repeated itself.
Initially he thought the researcher only came for his in-law burial funeral, but the man came for to save his people lives. Having tested the efficacy of the divine fermented Naija natural HIV/AIDS at that very particular point in time, in side him he failed a dramatic change in the body after 15 minute or thereafter. He went straight and told his wife there is something their visitor gave him it appears so strength in comparison to the antiretroviral drugs he always takes. The wife asked him where is the drugs and he joyfully brought it out and shown her the miraculous drugs. Having does the wife has taken the miraculous drugs, her heart quickly jumped into her mouth with surprise by reporting to her husband like wise. The next following morning the common Dr. as the head village love to call the researcher Dr. my wife and I are feeling quite great and Olympic. Initially when the researcher saw them it appears as if they were not clinically sound but after that at 65 (Husband) or so and wife at 62 or so they were just feeling strong and Olympic. She quickly ran into kitchen for morning breakfast before she finally went to office (Primary school teacher). The next following morning he took the Dr.
for a stroll within the local villages and to his sister whom the Dr/ researcher saw and he felt grief on her condition. Thereupon the researcher opens up for his physical and spiritual assignment, Chief this your sister has pile, diabetes, ulcer, high blood pressure but third one I wound not let the cat out of the bag for your hearing. The head village scream and shouted this man you are not ordinary. The researcher asked him to please give her the divine therapy for our God to be known. Having taken the natural drugs and next following morning she came to her brothers with full of joy. By and large there searcher felt he was sleeping too long in the village head bed; therefore, he asked the head village have they buried Chief George Bengioshuye Agba and how was their tradition regarding to burial funeral?
He did tell the researcher that Late Chief George Bengioshuye Agba would be buried tomorrow and we shall be going there and sleep by the tomorrow everything would have been come to an end. From Ishiborito Ogoja is about 40 km or their after, having arrived at the Ojojavillage in some few minute then the corpse of Late Chief George Bengioshuye Agba was brough in the compound. There with the corpse was kept in a beautiful decorate modern hut over night before Late Chief George Bengioshuye was buried. The retired general Peter Abobo Agba saw me and felt so happy and called the researcher byhis father's name Silas in Hausa" har ka samu ka so? He then pictures there searcher and found that he was such a responsible person right when he had known the researcher at child hood. While thinking where the son of man would have laid his he for tonight before taken up to Kaduna. Suddenly ahillock Bus came at the point of where the researcher would have slept along side with general who was the driver with a soldier on security came and took the researcher to a Hotel by name Kuciano hotel Obudu as seen in plate 3 and 7 the local champion has become and international champion. There is a significant difference between plate 3, 7 and plate 2. Well, if the Head village would have known he might have taken the researcher to powerful hotel for him to enjoy with the babes around for that night.
But the head village was just a retiree and pensioner for that matter and the difference was quite clear and no controversy in comparison with the retired general. While the general/his security on guard and the researcher were heading to the hotel for him to have rest, the researcher opens up his mission to him.
The researcher mission was for his elder brother burial funeral as (primary issue) and the secondary issue was to save lives of the communities from the lingering killer disease that have been ravaging people lives to their early grave. The products were produced in Kaduna polytechnic in the directorate of research and innovation. Thus, they were just natural herbal drugs and they are very effective.
Therewith there searcher handed everything to him and we shall hear the feedback through the former Rector of Kaduna Poly now the Executive secretary of NBTE. The registered name would have been included but his phone number was not where to be found in my Handset. "Kai" see fine girls men…….. in the hotel but I was afraid to touch any because of the HIV status. As instructed do not collect anything from anybody and so the researcher remain faithful to the instruction.

Spiritual/Physical Inspiration without it no Scientific Discoveries
As a matter of truth scientists, lecturers, medical doctors etc., respectively have done quite well in keeping humanity in the right track. To be candid, let it be known to every respected profession. The spiritual happening is far much greater than the physical. When most researcher lives a sinless /holy life and follow the precept of the marker of heaven and earth planet then they can visualize any tiny object be young the physical realm. Thus, life will go a long way and smoothly with mankind's. Scientist believed strongly in "seeing and believe" by physical means, but in some cases physical means objects are limited in comparison with spiritual means. Most illnesses in some cases can not be virtualize by the use of physical means material because they are limited. The spiritual always come in existence with everlasting promises while the physical with fake promises and limited in-situ. Most medical doctors and scientists are more prone tophysical happening than the spiritual. Thus, when a patient case is far beyond human understanding using physical object, they normally referred him/her to spiritual professional for lasting solution or otherwise. The current researcher is more of a spiritual mean than the physical or both. For this reason, most of the physical materials event that we are seeing these days must have happened in the spiritual before they manifest in the physical. For Instant, the inventor of plane does not start fly without an inspirational messages or sources. Likewise, the inventor of a car does not start moving with a car not until he/she has been inspired. Do the medical doctors start practicing his/her profession without and inspired word or source? In question, where do the sources of number of natural proteins both at the primary metabolites/secondary metabolites stages; hence, the net products are the production of microbial enzyme, vitamins, and so many, amino acid residues, vaccine, antibiotic, and isolates demand for organic synthetic that makes the huge number of natural proteins as seen in Table 2. At the secondary metabolites phase when the substrate has gone delated, then the rejuvenation not of but through phytochemicals comes up i.e., the fall of someone would have given birth to the rise of another person (anthraquinone, flavonoid, tannins, polyphenolic compounds, that target the HIV/ COVID-19 viral truck load as seen in the table 1 and 4. For the research done so far, for the Naija divine fermented herbal therapy, it was harvested at primary/Stationary phase. Point of correction as the suitable substrates or medium gone devastated by microbial spoilage at the death phase, the test and aroma or the net effect is an obnoxious odor like those of smelling dead rat inside the cardboard. In as much as the divine Naijaharvested herbal therapy is likening by most people at primary phase/stationary phase in-situ in plate1. So far, the product was then harvested at the required norm for sundry/ microbial ovum dryer in readiness for milling and encapsulation. As seen in plate 9.
Please scientist or the lay men get the researcher right, at the point of primary stages (exponential   and secretly wanted to escape God instructions to another location. Unfortunately, the ship Jonah boarded was found shaken by strong storm that let the people inside the ship to have thrown him inside the sea after admitting his fault. Thus, Jonah was swallowed by a whale and have been in the whale belly for good consecutive 3 days, and after he was vomited by the whale at the bank of the river.
Suddenly Prophet Jonah Worship God and went straight for the errand. However, they don't tell person train is coming or otherwise. Thereupon when the message of God through prophet Jonah touches their heart (People of Nineveh) so they repented and eventually the wrath of God went into the air without hurting them. As seen in Figure 23. The word of the LORD came to Jonah son of Amittai: 2 "Go to the great city of Nineveh and preach against it, because its wickedness has come up before me." But Jonah ran away from the LORD and headed for Tarshish. He went down to Joppa, where he found a ship bound for that port. After paying the fare, he went aboard and sailed for Tarshish to flee from the LORD. Then the LORD sent a great wind on the sea, and such a violent storm arose that the ship threatened to break up. 5 All the sailors were afraid and each cried out to his own god. And they threw the cargo into the sea to lighten the ship.But Jonah had gone below deck, where he lay down and fell into a deep sleep. 6 The captain went to him and said, "How can you sleep? Get up and call on your god! Maybe he will take notice of us so that we will not perish." Then the sailors said to each other, "Come, let us cast lots to find out who is responsible for this calamity." They cast lots and the lot fell on Jonah. 8 So they asked him, "Tell us, asked, "What have you done?" (They knew he was running away from the LORD, because he had already told them so. The sea was getting rougher and rougher. So they asked him, "What should we do to you to make the sea calm down for us?""Pick me up and throw me into the sea," he replied, "and it will become calm. I know that it is my fault that this great storm has come upon you. Instead, the men did their best to row back to land. But they could not, for the sea grew even wilder than before. Then they cried out to the LORD, "Please, LORD, do not let us die for taking this man's life. Do not hold us accountable for killing an innocent man, for you, LORD, have done as you pleased." 15 Then they took Jonah and threw him overboard, and the raging sea grew calm. At this the men greatly feared the LORD, and they offered a sacrifice to the LORD and made vows to him. Now the LORD provided a huge fish to swallow Jonah, and Jonah was in the belly of the fish three days and three nights. Jonah1: 1-15. As seen in Figure 23.

Figure 9. Posted Moses and the Ten Commandments
At the generation of grace, i.e., this generation everyone seems to be toiling or playing with sins at his/her own will when God Almighty has laid down principle for men to immolate his precepts/commandments through his written hand as seen in fig. 23  to now there is no cure; except, Suppressions through Antiretroviral therapy/ Higher active Antiretroviral therapy. Another noble pandemic Covid -19 is around the corner ravaging people live to their early grave and scientist have claimed they have gotten the vaccine when it is not. This will continue to be like HIV pandemic when HIV carrier patents are under (ART/HAART) made of up synthetic chemicals ingredients with many lingering side effects. For these reason God is sending strong warning messages to mankind's to shun deliberate sin of fornication, sin of abortion, sin of homosexual, sin of having sex with small children (Pedophilic), sin of Gay married, another sin in Hausa language "Dan daudu" is more or less have sex man to man, Bestiality (Sex with animals or animal having sex with man). This sound warning is on everyone, least God will one day destroy humanity with methane, Sulphur and volcanoes fire as hot as furnace. Let those who have ear to read the article to change for the better, for only those whose are found of fallen into pang of frustrating and disappointing God's precepts on earth planet will be destroy. Thus, the good ones will be taken to heaven and the earth will remain as it is for another generation to continue the race. The angels then proceed to blind all the men of Sodom and Gomorrah and urge Lot and his family to flee from the cities to escape the wrath that God was about to deliver. Lot and his family flee the city, and then "the LORD rained down burning sulfur on Sodom and Gomorrah -from the LORD out of the heavens. Thus he overthrew those cities and the entire plain, including all those living in the cities..." (Genesis 19:24).
In light of the passage, the most common response to the question "What was the sin of Sodom and Gomorrah?" is that it was homosexuality/gay, rapping, abortion, fornication bestiality, pedophilic dubious activities etc., respectively . That is how the term "sodomy" came to be used to refer to anal sex between two men, whether consensual or forced. Clearly, homosexuality was part of why God destroyed the two cities. The men of Sodom and Gomorrah wanted to perform homosexual gang rape on the two angels (who were disguised as men). At the same time, it is not biblical to say that homosexuality was the exclusive reason why God destroyed Sodom and Gomorrah. The cities of Sodom and Gomorrah were definitely not exclusive in terms of the sins in which they indulged.

Conclusions
Once the first incident of HIV infection was reported in 1981, its implications and symptoms brought much concern to clinicians and researchers. Its global spread presented a serious problem. The subsequent opportunistic diseases from infection and slow progression to AIDS were alarming. Novel advances in diagnosis and treatment brought much hope to researchers. They believed that if it were possible to catch the infection at an early stage and the agents that led to its life-threatening consequences, treatment might alter the course of these agents and save lives. However, as most virologists had known, this would be no simple task.
ROS were found to play a critical role in accelerating and controlling the progression to AIDS. In addition, antioxidant depletion was found to be a common sign at the onset of HIV infection, which resulted in severe OS. This imbalance gave way to pro-oxidants that activated replication and transcription pathways of the virus. Therefore, it was thought that antioxidant supplementation might

Expert Commentary
HIV/AIDS has developed into a global problem that shows no sign of ceasing any time soon. Several studies indicate new advances in diagnosing and treating the infection, yet almost all remain costly.
Antioxidants offer a promising, natural, and inexpensive remedy that may not only alter the course of HIV infection to AIDS, but also prove invaluable in reaching out to poverty-stricken countries.

Five-Year Review
There has been extensive study in the pathogenesis of HIV/AIDS over the past few years. An overwhelming number of treatment studies focus on the use of protease inhibitors and antiretroviral agents rather than antioxidants. However, a majority of these reports face tremendous difficulty due to the ever-mutating HIV strains. Although the mutations have no effect on the virus, the genetic flexibility permits drug resistance and the virus to escape the body's immune system.
A majority of research has focused on the use of highly active antiretroviral therapy (HAART) to suppress HIV viral replication and the progression of HIV disease. The hope is that daily treatment will stop any further Attenuating of the immune system, and thus, allow it to recover from any injury already caused. Reports have revealed HAART regimens that have successfully controlled AIDS and its related disorders, as well as reduced the amount of active virus to undetectable levels at times.
However, recent studies have indicated a rise in prevalence of HIV-1-associated neurocognitive disorders and related side effects following the era of HAART. An in vitro study investigated whether HAART drug combination of AZT and Indinavir (IDV) may alter the Blood-Brain Barrier (BBB) endothelial cells, which may exacerbate this condition. Following 72 hours of treatment, the viability of the cells was significantly reduced in a dose-dependent manner and levels of ROS were highly elevated.
AZT+IDV treatment also induced apoptosis in endothelial cells. Interestingly, pretreatment with NAC reversed some of the pro-oxidant effects of AZT+IDV. The authors suggested that this AZT+IDV combination treatment might affect the BBB in HIV-infected individuals treated with HAART drugs.
An additional study investigated the related side Effects of Efavirenz (EFV), which is another widely used treatment for HIV-1 infection. Similar to previously discussed study, viability was reduced in a concentration-dependent manner and EFV triggered apoptosis. EFV also lowered cellular proliferation and directly affected mitochondrial function in a reversible fashion by decreasing mitochondrial membrane potential and increasing superoxide production. As previously demonstrated, this study found the toxic effect of EFV treatment to be partially reversed by antioxidant pretreatment.
The elevated levels of ROS in each study indicate HAART generates ROS, thereby provoking the onset of OS, which has already been well established to occur upon HIV infection. Hence, while the oxygen faces a paradox, so does HAART: although viral loads may be suppressed, it is at the expense of elevated ROS levels that are known to only activate HIV transcription pathways and promote cell death.
Therefore, since NAC treatment has been demonstrated to suppress some of the pro-oxidant effects of antiretroviral treatment, antioxidants in combination with HAART may reverse neurocognitive disorders and additional opportunistic infections associated with HIV-1 infection, while still working to reduce viral loads. Since a substantial amount of evidence reveals a role of ROS in inducing OS following HIV infection, and OS as a causative factor in the progression of many diseases, including AIDS, a turn of focus should be put on antioxidants as natural and inexpensive therapeutic agents to suppress the consequently life-threatening disease. Future studies should be undertaken to determine the correct dosages and duration of antioxidant treatment necessary to curb the adverse effects of HIV infection. Furthermore, comparative studies may serve to identify co-factors that contribute to the development of AIDS. With a better understanding of the co-factors that assist in progressing the disease, there is tremendous hope of improved diagnosis and treatment to perhaps alter the course of HIV infection and prevent the onset of AIDS.