AI Positioning and Navigation, Robot Operation, Precise Intervention of Chemotherapy Drugs into the Osteolytic Destruction Area of the Distal Femoral Metaphysis, Implementing Direct Chemotherapy within the Solid Tumor of Osteosarcoma

Abstract

MAP regimen is a classic chemotherapy protocol for osteosarcoma. On the basis of MAP reginen, we have made three adjustments and ultimately developed an innovative regimen for direct chemotherapy in the solid tumor of osteosarcoma specifically tailored for this patient:

1). Adjust the drug supply method from intravenous infusion to static pulse injection pump micro-volume slow push

2). By AI positioning navigation, robot operation, static pulse injection pump micro-volume slow push, the chemotherapy drugs are accurately involved into the osteolytic destruction area of osteosarcoma, and implementing direct chemotherapy in the solid tumor of osteosarcoma.

3). Combined with autologous leukocyte implantation

The patient successfully completed the direct chemotherapy in the solid tumor of osteosarcoma, combined with autologous leukocyte implantation for 4 cycles before operation, the tumor volume was reduced by about 50%, tumor was sensitive to chemotherapy, with a tumor necrosis rate of over 90%, the clinical stage has been downstaged from IIA to a potentially resectable status, with clear boundaries and no distant metastasis, providing a favorable condition for surgical resection. Compared to targeted therapy and nanotechnology, this is a more direct and more precise approach to intratumoral chemotherapy. It indeed can increase the concentration of chemotherapeutic drugs within tumors by focusing drug delivery to the tumor site, enhancing the direct killing effect on tumor targets while potentially reducing systemic side effects.

The next step in the research plan is to implement direct chemotherapy in the solid tumor of malignant bone tumor while combining it with animal leukocyte transplantation, fully utilizing the particularity of immune rejection under the condition of confined space in a solid tumor to destroy the tumor microenvironment.