Methods and Advances in Behavioral Assessment of Spinal Cord Injury in Mice

Abstract

Spinal cord injury (SCI) refers to the direct or indirect external factors that cause the spinal cord to be damaged, and various sensory, motor and sphincter disorders, abnormal muscle tone, and pathological reflexes appear in the corresponding segments of the injury. Behaviorology is for research. The responses made by individual animal groups and animal communities to adapt to changes in the internal and external environments, and behavioral assessment is one of the important means to judge the extent of spinal cord injury and measure the efficacy of treatment. At present, clinical SCI is still very different from animal models, so a complete and objective motor evaluation system is needed. This paper systematically evaluates the motor function evaluation methods and their respective advantages and disadvantages of various SCI mouse models, and publishes research The user selects appropriate models and evaluation methods according to the needs of experimental therapies.