The Role of Basic Leucine Zipper and W2 Domain Containing 2 (BZW2) in Endometrial Cancer: Implications for Tumor Progression and Patient Outcomes

Abstract

Background: This study investigates the role of basic leucine zipper and W2 domain-containing 2 (BZW2) in endometrial cancer (EC) and its implications for tumor progression and patient outcomes. We assessed the expression of BZW2 in endometrial cancer (UCEC) and its correlation with tumor progression, clinical pathological features, and patient prognosis.

Methods: We utilized RNA sequencing data from the TCGA and UALCAN databases to analyze BZW2 expression patterns in EC and its association with tumor grade, stage, patient age, and prognosis. Additionally, we explored the molecular relationships between BZW2, various signaling pathways, and immune cell markers. The role of BZW2 in endometrial cancer cell proliferation and migration was validated through cellular experiments.

Results: Our analysis revealed elevated BZW2 expression in EC, which correlated significantly with tumor grade, stage, and patient age. Prognostic analyses indicated that high BZW2 expression was associated with reduced overall survival and progression-free survival. Molecularly, BZW2 was linked to several signaling pathways and immune cell markers, while cellular experiments confirmed its role in promoting endometrial cancer cell proliferation and migration.

Conclusion: The multifunctional role of BZW2 in endometrial cancer highlights its potential as both a therapeutic target and a prognostic biomarker. Our findings provide compelling evidence supporting BZW2 as a promising target for the treatment and prognosis evaluation of UCEC, thereby guiding future research and clinical applications.